But while there is a sense of exasperation among the players about the training methods and the intensity of training at key stages of the week, and also Wenger's inability to connect with modern players as he did with his squad during the club's successful period of the late 1990s and early 2000s, there are some at Arsenal who believe the players have also let themselves and Wenger down.
The Frenchman told reporters following a 2-1 defeat at Brighton: "I left him at home because I played him in the two games against City, without a lot of training in behind". "These players want to win, in life you forget quickly how good you are". Players change their mind quickly.
"[We need] to set reachable targets, focus on what you can do better and not be scared too much about the consequences of a bad result".
The Rossoneri have enjoyed a resurgence under former midfielder Gennaro Gattuso of late while Wenger's reign appears to be wilting to a close, with numerous Arsenal supporters backing his exit sooner rather than later.
Gattuso indicated he was looking forward to the challenge of facing Wenger, describing himself as a "rookie" compared to the veteran French manager, but the Gunners boss conceded that with Arsenal struggling badly he could learn from his counterpart.
"In my opinion it will be a tight tie, because Milan is doing well at the moment".
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"I didn't want to gamble today for a physical setback, so I left him completely out of the squad".
"It makes me think about last year, but last year we made 75 points in the Premier League and missed out on the Champions League by a point", Wenger said.
"This is an opportunity for us and we have to take it". I can't see that at the moment because two teams to drop so many points is very hard to imagine.
Now coming under huge pressure to leave at the end of the season, it is understood that only a return to Europe's elite competition will allow Wenger to see out the final year of his contract.
"What you want is to to show that you have the quality and the strengths, and you can only show that when it is hard".