The midfield trio of Nemanja Matic, Scott McTominay and Juan Mata performed admirably in Pogba's absence against Liverpool, but Mourinho would certainly to have Pogba back in the centre as he looks to book a place in the Champions League last eight.
Defender Gary Cahill, who was injured in that game, said: "I didn't spend too long out there last time with my hamstring that I pulled.
So, of course, knockout becomes more important than league matches".
Joaquin Correa headed just over from a corner before Luis Muriel and Franco Vazquez fired off target when well-positioned on the edge of the area.
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During the standoff, the apartment building had been evacuated as a SWAT team maintained a watch all night and all morning long. A man to look up to. "He left his family at home to protect yours and his ultimate sacrifice will never be forgotten".
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"Can he play against Sevilla?". The return of Eric Bailly in defence has been great, despite his own goal against Liverpool. "The second goal made it impossible".
Pogba, who cost United a then-world record £89 million (S$160 million) in 2016, was eventually introduced just after the hour mark with Fellaini sacrificed.
Ben Yedder came off the bench to add another attacking dimension in the 72nd minute and within six minutes had ended the tie, following a fine low strike with an effort that De Gea could not prevent from crossing the line.
Should he come back even if he is?
There is still no place for Zlatan Ibrahimovic despite his continued involvement in training, with Mourinho having confirmed recently that he is leaving the final decision over a return date down to the Swede himself as he looks to shake off the lingering effects of ACL damage.
Lukaku blazed wide in the second minute after a smart one-two with Jesse Lingard created an early opportunity for United.