The 25-year-old picked up an injury in the first-leg after a thumping 3-0 win but failed to feature in the 0-0 draw with Everton at Goodison Park. "We will train and then make a decision".
But Tuesday night offers Guardiola and City the chance to show that his pursuit of perfection does have a reachable final destination.
"He was training yesterday and now I am here".
"We have the chance to do something unthinkable, considering that they practically haven't lost - a miracle if you will", Di Francesco said.
"What we need at Liverpool are these kind of players who are leaders", said Klopp recently on Van Dijk's influence.
Roma also have a lot of work to do in their Stadio Olimpico clash with Barcelona as they trail 4-1 from the opening leg at the Camp Nou. "It is all about going into the next round".
A spot in the Champions League semifinals, with Liverpool looking like the heavy favorite following the convincing 3-0 win over City in last week's first leg.
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They score goals like no other team in England, and Guardiola still believes that City can claim an historic victory against Jurgen Klopp's men.
There's no denying that Klopp has made Liverpool better - as he has done with every team he has coached.
"Without them, Liverpool look half the team they were against City and while I would not point an accusing finger at Solanke and Ings for that, the reality is they are not at the same level as Salah and Firmino".
"I don't think three will easy for them but we need to be ready and a goal is always a good idea". It was not easy.
The referee will be Antonio Mateu Lahoz, who Guardiola criticised recently, saying: "I remember what happened past year". City has the chance too.
"Obviously, we are bothered by the last two games".
"Most of the people think Liverpool will go through but will lose the game". Nothing is fixed. We have the chance to win.
"It is nice to play in that stadium where you were for a couple of years and didn't get a first-team appearance - at least I get to play now", said the German, who spent two seasons at City between 2009 and 2011 as a teenager but only played for the under-18s and under-21s. We have another chance in the Champions League, it's not easy, but we'll fight for that.