If Real beat Atletico in Sunday's Madrid derby and Barca win their next four fixtures, Ernesto Valverde's side will have clinched a 25th title by the time of the Clasico on May 6 at the Nou Camp.
Despite their vast improvement in 2018, Real Madrid will be looking to overhaul their squad with major summer signings having several Premier League talents on the radar.
Barca lead the Liga standings by nine points over nearest challengers Atletico Madrid and are 13 ahead of third-placed Real with seven games remaining.
Before the rivals met in December, Barcelona director of institutional relations Guillermo Amor announced Real Madrid would not be ceremonially welcomed despite Los Blancos' triumph over Gremio to win the FIFA Club World Cup.
"We will not give a guard of honour, this is my decision", said Zidane on such a possibility. His goal tally in the ongoing league season stands at 38 goals in all competitions, and he stands a chance to increase it if he avoids injury before the end of this term.
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According to the Manchester Evening News the Spanish giants have let United know that they would be prepared to use long-term Red Devils target Gareth Bale, as well as classy midfield duo Luka Modric and Toni Kroos in any deal.
"I would understand if he wasn't feeling as motivated, because players want to play every game".
In one of the most packed weekend's of the season thus far, Pep Guardiola will come up against his old foe Jose Mourinho in Saturday's late kick-off, with the game getting under way at 5:30pm. He is an important player.
However, Zidane, is hoping that Wales's all-time record goalscorer would stay at the club beyond this season.
There have only been three previous occasions in which a guard of honour has been presented in meetings between Real Madrid and Barcelona.