When they came back out on Tuesday, Del Potro completed a 7-6 (7-1) 7-6 (7-5) 5-7 7-6 (7-5) victory on Court Two, but only after sealing the win with his fifth match point.
Like Nadal, who could strike Djokovic in the semis, Federer hasn't dropped during his charge to a 16th Wimbledon quarter-final, nearly surely a staggering record that will never be surpassed.
The legendary Swiss, eyeing a ninth title at SW19, will now await the victor of either eighth seed Kevin Anderson and Gael Monfils.
"I will try to hold my service games most of the time".
"It's definitely helped a certain style of player, maybe the big servers", said 20-time major victor Federer. Nadal then plays Jiri Vesely of the Czech Republic.
Like his great rival Federer, Nadal has cruised through to the last eight without dropping a set.
Eight-time champion Federer will play on Court One for the first time since the 2015 quarter-finals, with former world number one Djokovic's match against Nishikori put on Centre.
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We have everything needed to do that, a great team, great staff and I hope we will make the extra step, ' he said. The defender is not ready for his World Cup dream to be over as he targets a first England final since 1966.
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It means Nadal is now in his 35th Grand Slam quarterfinal and following previous years of injuries and bad luck at SW19, the Spaniard was pleased to reach the last eight. Philipp Kohlschreiber, who lost to Anderson in Wimbledon's third round, said " if he believes (he can) beat Roger on grass, I think he can do it, because the game is big".
Del Potro was leading 7-6 (7/1), 7-6 (7/5), 5-7 when his tie with Simon was halted for the night due to darkness.
The three-time champion, who has not reached a Slam semi-final since the 2016 US Open, clinically despatched Karen Khachanov in the last 16 and will be considered favourite to beat Nishikori.
"He doesn't get affected too much by the big occasions". "I got a lot of first serves in, made him hit the extra ball". "It was hard in the last few games".
Federer, who plays Kevin Anderson in the quarter-final of the Wimbledon is on course for a ninth title at the iconic All England Club was invited by Tendulkar to exchange notes about cricket after he wins his ninth crown. His problem has always been the first week of Wimbledon, not the second week.
The cricketing body "admitted" that shot was actually good and joked about ranking Federer as the No. 1 Test batsmen in the World.
I think their level is just so high that it will take one of them nearly freak players to beat them.