Sharapova collected the trophy in NY at age 19 in 2006 and owns a total of five Grand Slam titles, but the Russian was far shakier during this match than Suarez Navarro, who never has made it past the quarterfinals at a major.
Sharapova matched her performance from a year ago but then, in her first Grand Slam since the end of her doping ban, the fourth round seemed a sign she could return to her best.
The 13-times grand slam victor had made easy work of the opening set, breaking Sousa twice, the second time to close out the set.
Asked if Monday's defeat represented the most challenging period of her career, Sharapova - who left Russian Federation for the United States with her father as a seven-year-old - said: "What's challenging is when you're a teenager and you have a few hundred dollars and you've got no sense of the future". This time I don't want to feel like previous year.
Osaka reached her first Grand Slam quarter-final, tearfully admitting she was prepared to "break a leg" to win the match.
Since her championship, Sharapova has only once made it to the quarterfinals at the U.S. Open - in 2012, when she lost in the semifinals.
"I think it was some type of heat illness or something like that", Tsurenko said.
Maria Sharapova has been unable to find her mojo since returning from her doping ban for using a Russian super soldier serum in 2017.
Her bitterest rival Serena Williams, after four rounds, has just nine double faults and has been broken only three times. Suarez, who turned 30 on Monday, is playing her eleventh US Open and made it to the quarter-finals for the second time after her first quarter-final in 2013, reports EFE news agency.
Suarez Navarro often let the 22nd-seeded Sharapova create her own problems.
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Keys punched her ticket to the quarterfinals with a dominant 6-1, 6-3 victory over No. 35 seed Dominika Cibulkova of Slovakia. Keys lost to Sloane Stephens in last year's final, and also lost to Stephens again this year in the French Open semifinals.
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"I need to be aggressive. try to be solid, run and fight".
Madison Keys (USA) bt Dominika Cibulkova (Svk) 6-1 6-3, Naomi Osaka (Jpn) bt Aryna Sabalenka (Blr) 6-3 2-6 6-4, Lesia Tsurenko (Ukr) bt Marketa Vondrousova (Cze) 6-7 (3-7) 7-5 6-2.
"It will be a really tough match [against American Keys]". She was good in some ways.
Vondrousova accused Tsurenko of putting on an act, but the Ukrainian insisted her struggles were real, saying: "I don't know what to say. She has a great serve and plenty of experience on this court". This is the way that I can play really good tennis.
From there, Suarez Navarra took the momentum and rallied through the rest of the match, cruising to the 6-3 win.
"The belief is not something that I'm eager to show everybody else", Sharapova continued.
The No. 19 seed Latvian said it is always tough to play Stephens - her ball is heavy and she generates a lot of spin on both her forehand and backhand, Sevastova said during the news conference.
Sabalenka, who saved three break points in the final set, flung her racket in dismay after committing a double-fault on match point, handing victory to her 19th-ranked opponent.
"I just couldn't get into my game".