As lawmakers took to the Senate floor on Friday to vote to advance Brett Kavanaugh's nomination to the highest court in the country, a group of men took over the street just outside the Supreme Court to protest, chanting, "Believe women!".
While the vote was a victory for the Republican Party, politicians can vote differently on the climactic confirmation roll call, which seems likely to be on Saturday afternoon.
Following the vote, President Trump said that he is "very proud" that the Senate has cleared the way to hold a vote on Kavanaugh.
Amid strong indications that Murkowski would again vote "no", that meant Kavanaugh would win final approval unless both Manchin and Republican Susan Collins of ME switched from backing Friday's procedural vote to opposing confirmation.
Majority Leader Mitch McConnell, who helped push through Kavanaugh's nomination despite moments where it looked like it could fail, effusively praised Kavanaugh.
Supreme Court nominee Brett Kavanaugh's fate was in doubt for almost a month after the first accusation against him.
McConnell added he knew he what he had to do when he filed the cloture motion last week.
Ms Murkowski sat solemnly during the roll call and whispered "No" when it was her turn to vote.
After remaining undecided on whether Kavanaugh's nomination should move forward, Murkowski rendered her decision Friday in dramatic fashion.
The outcome, telegraphed Friday when the final undeclared senators revealed their views, was devoid of the shocks that had come nearly daily since Christine Blasey Ford said last month that an inebriated Kavanaugh tried to rape her at a 1982 high school get-together. She said on the Senate floor Friday evening that Kavanaugh is "a good man" but his "appearance of impropriety has become unavoidable".
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Mr Flake later said he will vote to confirm Mr Kavanaugh "unless something big changes". If there is a 50-50 tie, Vice President Mike Pence will cast the deciding vote.
Their signatures are part of a letter from more than 2,400 law professors against the approval of Kavanaugh to the Supreme Court.
Rep. Joe Manchin of West Virginia, confronting a tough re-election race next month in a state that Trump won in 2016 by a landslide, was the sole Democrat to vote in favor of Kavanaugh.
Today's vote comes after Kavanaugh faced accusations of sexual misconduct from Ramirez and other women. "With the Kavanaugh nomination, it has finally hit rock bottom", said Collins.
This mutual friend was identified to the Federal Bureau of Investigation by Deborah Ramirez as a witness to the sexual misconduct Kavanaugh allegedly committed against her at a college party in which he shoved his genitals in her face.
The dramatic Senate floor announcement by perhaps the chamber's most moderate Republican ended most of the suspense over a tortuous, election-season battle that had left Kavanaugh's fate in doubt for almost a month after the first accusation against him.
Justice Anthony M. Kennedy, (Retired) administers the Judicial Oath to Judge Brett M. Kavanaugh in the Justices Conference Room, Supreme Court Building.
Although some polls have shown increasing Republican enthusiasm ahead of the November midterm elections that will determine control of Congress, Kavanaugh's support among voters as a whole is historically low.
Kathy Charlton, who attended Yale University with the judge, disclosed a text message conversation to NBC News between herself and an unnamed mutual friend of Kavanaugh's. They said he also seemed ready to knock down President Barack Obama's health care law and to rule for Trump if federal authorities probing his 2016 campaign's connections to Russian Federation initiate legal action. Two other women also emerged and accused him of other incidents of sexual misconduct.