Migraine is a neurological disease caused by genetics and a hypersensitive brain. #MHAM
It is a neurological disease and not just a headache. It is hard for people to grasp this little fact. I once made a somecard about it in fact:
The genetics of it is interesting to me. My little brother Dominic has silent migraines. My younger brother Martin has chronic migraines and cluster headaches. My father has chronic migraines. And I have chronic migraines. The genetic factor is there.
I am particularly interested in the MTHFR gene myself. I have migraine with aura, but good luck getting neuros in Canada to do genetic testing. Still it would be interesting to know if massive about of B Vit would be a benefit.
Migraines and other forms of primary headache are caused by a combination of genetic and environmental factors, with MTHFR, KCNK18, TRPV1, TRPV3 and HCRTR being cited as the major genes influencing the condition. MTHFR C677T is the most studied in relation tomigraines.
The categorization of a migraine as a vascular disorder brings MTHFR to prominence andmigraines are related to “stroke, myocardial infarction, hypertension and Raynaud’s phenomenon.” Elevated homocysteine, a frequent feature for those with MTHFR C677T, disrupts the inner lining of the nerves and blood vessels, which can contribute to migraines. It also produces neurotoxic effects and hyperexcitability in the brain’s neurons.
One of the linked studies found that lowering homocysteine through vitamin supplementation reduced migraine disability.MTHFR also affects the characteristics of migraine symptoms. A Russian study found that “the ТТ genotype was associated with migraine with aura and unilateral headache, the СТ genotype was associated with physical activity discomfort and stress as a migraine trigger.” Migraine Again